Neonatal Procalcitonin Intervention Study (NeoPInS): Effect of Procalcitonin-guided decision making on Duration of antibiotic Therapy in suspected neonatal early-onset Sepsis: A multi-centre randomized superiority and non-inferiority Intervention Study

Table 2 Assessment guidelines

Pre/perinatal risk factors	Mother group B streptococcus (GBS) positive
	Maternal prolonged rupture of membranes (PROM) > 18 h
	Maternal chorioamnionitis (fever >38.5°, fetal tachycardia)
	Birth before 35 weeks of gestational age
6 groups of suspect clinical signs and symptoms	Respiratory distress/apnea
(signs and symptoms of one group = one abnormal finding)	Tachycardia/bradycardia
	Arterial hypotension/poor perfusion
	Hypothermia/hyperthermia
	Seizure/floppy infant/irritability/lethargy/poor feeding
	Vomiting/feeding intolerance/ileus
Conventional laboratory examinations	White blood cell count < 5 G/L
	CRP > 10 mg/L

ISSN: 1471-2431