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Table 4 OM risk factors, by vaccination group

From: Otitis media in children vaccinated during consecutive 7-valent or 10-valent pneumococcal conjugate vaccination schedules

 

PCV7

PHiD-CV10

Absolute difference in mean or % [95% CI]

P*

 

N

Mean (SD) or %

N

Mean (SD) or %

  

Risk factor questionnaire response

No parents consented

413/444

93%

296/451

66%

−27% [−32 to −22]

<0.0001

Mother interviewed

400/413

97%

290/296

98%

1% [−1 to 3]

0.36

Characteristics of children in consented subgroups

 

PCV7

PHiD-CV10

  

Age (months)

413

20 (8)

296

18(7)

2.0 [0.9 to 3.2]

0.0008

Sex (female)

198

48%

151

51%

3% [−4 to 11]

0.42

Any Suppurative OM

208/395

53%

104/285

36%

−16% [−24 to −9]

<0.0001

Risk factors

Crowding (persons per household)

402

8.6 (4.5)

290

8.2 (3.9)

−0.4 [−1.0 to 0.3]

0.23

Crowding (children < 5 years of age per household)

408

2.4 (1.6)

291

2.1 (1.2)

−0.3 [−0.5 to −0.1]

0.01

Crowding Index (%households with > 2 additional children < 5 years of age)

132/408

32%

75/291

26%

−6% [−13 to 0.2]

0.06

Child Care (any attendance > 3 days per week)

51/409

12%

41/295

14%

1.4% [−4 to 7]

0.58

Child Care (days/week)

408

0.68 (1.7)

295

0.77 (1.7)

0.09 [−0.34 to 0.16]

0.49

Washed with soap yesterday

327/362

90%

258/293

88%

−2% [−7 to 3]

0.35

Any sibling with history of “runny ears”

101/370

27%

80/249

32%

5% [−3 to 12]

0.20

Child near campfire last week

134/402

34%

88/287

31%

−3% [−10 to 4]

0.46

Maternal smoking

233/410

57%

178/283

61%

4% [−3 to 11]

0.29

Maternal age at birth of this child

297

25 (5.4)

244

26 (6.4)

1 [0.1 to 2]

0.04

Maternal education (certificate)

105/382

27%

60/247

24%

−3% [−10 to 4]

0.37

Never breast fed

28/409

7%

14/296

5%

−2% [−6 to 1]

0.23

Pacifier (ever)

78/404

19%

52/296

18%

−2% [−8 to 4]

0.56

  1. *Bold signifies P value less than 0.05.