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Table 5 Prevalence of all forms of otitis media including combination categories, by vaccination groups

From: Otitis media in children vaccinated during consecutive 7-valent or 10-valent pneumococcal conjugate vaccination schedules

 

PCV7 444

PHiD-CV10 451

Absolute risk difference [95%CI]

P value

 

n

%

n

%

No. children without assessment

12

3%

14

3%

  

No. children with diagnosis based on tympanometry alone

4

1%

0

0%

  

No. children with unilateral otoscopy

27

6%

13

3%

  

No. children with bilateral otoscopy

401

90%

424

94%

  

No. children with at least one ear successfully assessed

432

97%

437

97%

  

Clinical diagnosis

PCV7 432

PHiD-CV10 437

  

normal

32

7%

41

9%

2% [−1 to 6]

0.29

OME

175

41%

222

51%

10% [3-17]

0.002

AOMwoP

150

35%

111

25%

−9% [−15 to −3]

0.003

AOMwiP

27

6%

24

5%

−1% [−4 to 2]

0.63

Dry Perforation

8

2%

5

1%

−0.7% [−2 to 1]

0.39

CSOM

40

9%

34

8%

−1% [−5 to 2]

0.43

Bilateral OME*

136/401

34%

191/424

45%

11% [4-17]

0.001

Unilateral OME*

24/401

6%

25/424

6%

0.1% [−3 to 3]

1.000

Combination OM categories

      

Any suppurative OM (AOMwoP, AOMwiP, CSOM)

217

51%

169

39%

−12% [−19 to −5]

0.0004

Any TMP (AOMwiP, DP, CSOM)

75

17%

63

14%

−3% [−8 to 2]

0.24

Any ear pain (today or last night)

34/408

8%

17/337

5%

−3% [−7 to 0.2]

0.08

Non-mixed PCV schedules

PCV7-only 353**

PHiD-CV10-only 319

  

No. children with at least one ear successfully assessed

345

98%

309

97%

  

Normal

24

7%

31

10%

3% [−1 to 7]

0.16

OME

127

37%

152

49%

12% [5 to 20]

0.001

Any suppurative OM (AOMwoP, AOMwiP, CSOM)

191

56%

121

40%

−16% [−24 to −8]

<0.0001

Any TMP (AOMwiP, DP, CSOM)

62

18%

48

16%

−2% [−8 to 3]

0.40

  1. *Laterality of OME could only be determined where bilateral assessments were successful; 401 PCV7 children and 424 PHiD-CV10 children had bilateral assessments.
  2. **138 children in the PCV7-only group had also received PPV23.