Pathogenesis of peroxisomal deficiency disorders (Zellweger syndrome) may be mediated by misregulation of the GABAergic system viathe diazepam binding inhibitor

Table 1 Ten genes that have expression profiles most similar to diazepam binding inibitor, DBI, in two large-scale microarray expression profiling studies, as quantified by Pearson correlation coefficient r (the top 10 neighbors of DBI are shown for each sample set, corresponding to r > 0.73 for the fibroblast samples). Genes that are mentioned twice refer to two independent clones on the array.

50 human fibroblast samples [22]		174 human carcinoma samples [21]
FDPS	farnesyl diphosphate synthase	DKFZP564B167	unknown function
HMGCS1	3-hydroxy-3-methylglutaryl-CoA synthase	IDI1	isopentenyl diphosphate isomerase
SC4MOL	sterol-C4-methyl oxidase	INSIG1	insulin induced gene 1
INSIG1	insulin induced gene 1	UAP1	UDP-N-acetylglucosamine pyrophosphorylase
H2AV	histone H2A variant	FASN	fatty acid synthase
FADS1	fatty acid desaturase	CYP51	lanosterol 14-alpha-demethylase
EBP	sterol-delta8,delta7-isomerase	C6orf34	unknown function
SQLE	squalene epoxidase	SC4MOL	sterol-C4-methyl oxidase
INSIG1	insulin induced gene 1	SORD1	sorbitol dehydrogenase
HMGCS1	3-hydroxy-3-methylglutaryl-CoA synthase	SYBL1	synaptobrevin-like 1

Bold genes are involved in lipid metabolism. The expression profiles can be explored and compared at http://genome-www.stanford.edu/fibroblast/figures.shtml (fibroblast samples) and http://genome-www5.stanford.edu/cgi-bin/source/sourceSearch (carcinoma samples).

ISSN: 1471-2431