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Table 3 Mortality: Cox proportional hazards models between baseline characteristics and death

From: Preliminary outcomes of a paediatric highly active antiretroviral therapy cohort from KwaZulu-Natal, South Africa

   Univariate analysis Multivariate analysis
Baseline Characteristic No. of Deaths Hazard ratio 95% CI p Hazard ratio 95% CI p
Gender      
   Male 6 1.00   1.00 -
   Female 7 1.14 (0.38–3.40) 0.810 2.78 (0.66–11.86) 0.163
Age      
   < 3 yrs 5 1.00   1.00 -
   3–5 yrs 2 0.35 (0.07–1.81) 0.210 1.37 (0.21–9.04) 0.747
   6–8 yrs 3 0.52 (0.12–2.16) 0.365 0.25 (0.02–2.93) 0.268
   ≥ 9 yrs 3 0.92 (0.22–3.85) 0.908 2.18 (0.44–10.85) 0.342
WHO clinical stage      
   Stage 1–3 7 1.00   1.00 -
   Stage 4 6 3.01 (1.01–8.95) 0.048* 1.82 (0.41–8.03) 0.430
Weight (**2 missing values)      
   ≥ 5 Percentile 1 1.00   1.00 -
   < 5 Percentile 10 8.60 (1.10–67.15) 0.040* 4.96 (0.45–55.31) 0.193
CD4% (**1 missing value)      
   ≥ 5% 5 1.00   - -
   < 5% 7 2.65 (0.84–8.34) 0.097 - -
Tuberculosis      
   Absent 5 1.00   1.00 -
   Present 8 3.39 (1.11–10.37) 0.032* 1.08 (0.25–4.59) 0.919
Pulmonary      
   Absent 9 1.00   - -
   Present 4 1.53 (0.47–5.01) 0.480 - -
Extrapulmonary      
   Absent 10 1.00   - -
   Present 3 3.06 (0.84–11.20) 0.091 - -
Chronic gastroenteritis      
   Absent 3 1.00   1.00 -
   Present 10 6.69 (1.84–24.30) 0.004* 12.34 (1.27–119.71) 0.030*
Pneumonia      
   Absent 9 1.00   1.00 -
   Present 4 5.23 (1.61–16.98) 0.006* 4.03 (0.79–20.54) 0.094
PCP      
   Absent 10 1.00   1.00 -
   Present 3 3.81(1.05–13.86) 0.042* 5.35 (0.84–33.86) 0.075
Oesophageal candidiasis      
   Absent 12 1.00   - -
   Present 1 0.92 (0.12–7.04) 0.932 - -
Hemoglobin      
   > 10 g/dl 5 1.00   - -
   ≤ 10 g/dl 8 1.87 (0.61–5.73) 0.272 - -
Primary caregiver HIV Status      
   HIV negative or unknown 10 1.00 - 1.00 -
   HIV positive 3 0.26 (0.07–0.95) 0.041* 0.12 (0.02–0.88) 0.037*
Primary caregiver receiving HAART at Sinikithemba      
   Primary caregiver not in care 12 1.00 - - -
   Primary caregiver in care 1 0.13 (0.02–1.01) 0.051 - -
Parent status      
   Two parent alive 6 1.00 - - -
   One parent alive 4 0.92 (0.26–3.26) 0.896 - -
   Neither parent living 3 0.82 (0.21–3.28) 0.778 - -