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Table 1 Growth screening rules with their definitions, interpretation of the used parameters and cut off (simulation) values (see method for details)

From: Screening rules for growth to detect celiac disease: A case-control simulation study

Screening rule

Definition

Parameter

Interpretation

Simulation values

Delta rule*^

For ages e 1 to 2.5 years, refer if

e 1

Age (in years) after which the rule is effective

0, 0.5, 1

 

(SDS2 – SDS1) <g 1

g 1

Change in SDS

-0.5,-1,-1.5,-2,-2.5,-3

Extended delta rule*

For ages e 2 to 2.5 years, refer if

e 2

Age (in years) after which the rule is effective

0, 0.5, 1

 

SDS2<f 1, AND

f 1

SDS cut off level below which the SDS2 must lie

-1,-1.3, -1.5,-2, -2.5

 

(SDS2 – SDS1) <g 2

g 2

Change in SDS

-0.5,-1,-1.5,-2,-2.5,-3

Slowed growth *

For ages e 3 to 2.5 years, AND

e 3

Age (in years) after which the rule is effective

0, 0.5, 1

 

X2 – X13/12 refer if

 

Minimal three months interval between ages X1 and X2

 
 

SDS2<f 2, AND

f 2

SDS cut off level below which the SDS2 must lie

-1,-1.3, -1.5,-2, -2.5

 

(SDS2- SDS1)/(X2-X1) < g3

g 3

Change in SDS per year

-0.5,-1,-1.5,-2,-2.5

Conditional weight gain rule

For ages e 4 to 2.5 years, refer if

e 4

Age (in years) after which the rule is effective

0, 0.5, 1

 

weight SDS2 <f 3 AND

f 3

SDS cut off level below which SDS2 must lie

-1,-1.3, -1.5,-2, -2.5

 

weight SDSgain = (weight SDS2 – r weight SDS1)/(√1-r2) <g 4

g 4

Change in SDS

-0.5,-1,-1.5,-2,-2.5

Absolute SDS rule*

For ages 0 to e 5 years, refer if

e 5

Age (in years) at which the referral level changes

0, 0.5, 1

 

SDS <f 4

f 4

SDS cut off level before age e 5

-1, -1.3, -1.5, -2, -2.5, -3, -3.5

 

For ages e 5 to 2.5 years, refer if SDS <f 5

f 5

SDS cut off level after age e 5

-1, -1.3, -1.5, -2, -2.5, -3

Parental height corrected rule

For ages e 6 to 2.5 years, refer if

e 6

Age (in years) after which the rule is effective

0, 0.5, 1

 

length SDS <f 6, AND

f 6

Length SDS must lie below this cut off level

-1, -1.3, -1.5, -2, -2.5

 

length SDS – TH SDS <g 5

g 5

Difference between length SDS and target height (TH) SDS

-1, -1.3, -1.5, -2, -2.5

Parental height deflection rule

For ages e 7 to 2.5 years, refer if

e 7

Age (in years) after which the rule is effective

0, 0.5, 1

 

(length SDS2 – length SDS1) <g 6, AND | length SDS2 – TH SDS | > | length SDS1 – TH SDS |

g 6

Change in length SDS Length SDS at age X1 is closer to it's target height than length SDS at age X2

-0.5,-1,-1.5,-2,-2.5,-3

Combined weight and length deflection rule

For ages e 8 to 2.5 years, AND

e 8

Age (in years) after which the rule is effective

0, 0.5, 1

 

(weight SDS2 – weight SDS1) <g 7, AND

g 7

Weight change in SDS

-0.25,-0.5,-1,-1.5,-2

 

(length SDS2 – length SDS1) <g 8, AND Y1 > X1

g 8

Length change in SDS Starting point length deflection (Y1) after starting point weight deflection (X1)

-0.25,-0.5,-1,-1.5,-2

  1. Several screening rules for growth were studied. Each screening rule consists of parameters that we have varied. For more details, see the paragraph screening rules.
  2. * Calculated for length (height), weight, and BMI
  3. ^For example, if e 1 = 0.5 year and g 1 = -2 weight SDS, then a child is referred if the second weight SDS measurement is -2 below the first weight SDS measurement and both weights were measured after six months of age (or at six months of age for the first measurement).