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Table 1 Growth screening rules with their definitions, interpretation of the used parameters and cut off (simulation) values (see method for details)

From: Screening rules for growth to detect celiac disease: A case-control simulation study

Screening rule Definition Parameter Interpretation Simulation values
Delta rule*^ For ages e 1 to 2.5 years, refer if e 1 Age (in years) after which the rule is effective 0, 0.5, 1
  (SDS2 – SDS1) <g 1 g 1 Change in SDS -0.5,-1,-1.5,-2,-2.5,-3
Extended delta rule* For ages e 2 to 2.5 years, refer if e 2 Age (in years) after which the rule is effective 0, 0.5, 1
  SDS2<f 1, AND f 1 SDS cut off level below which the SDS2 must lie -1,-1.3, -1.5,-2, -2.5
  (SDS2 – SDS1) <g 2 g 2 Change in SDS -0.5,-1,-1.5,-2,-2.5,-3
Slowed growth * For ages e 3 to 2.5 years, AND e 3 Age (in years) after which the rule is effective 0, 0.5, 1
  X2 – X13/12 refer if   Minimal three months interval between ages X1 and X2  
  SDS2<f 2, AND f 2 SDS cut off level below which the SDS2 must lie -1,-1.3, -1.5,-2, -2.5
  (SDS2- SDS1)/(X2-X1) < g3 g 3 Change in SDS per year -0.5,-1,-1.5,-2,-2.5
Conditional weight gain rule For ages e 4 to 2.5 years, refer if e 4 Age (in years) after which the rule is effective 0, 0.5, 1
  weight SDS2 <f 3 AND f 3 SDS cut off level below which SDS2 must lie -1,-1.3, -1.5,-2, -2.5
  weight SDSgain = (weight SDS2 – r weight SDS1)/(√1-r2) <g 4 g 4 Change in SDS -0.5,-1,-1.5,-2,-2.5
Absolute SDS rule* For ages 0 to e 5 years, refer if e 5 Age (in years) at which the referral level changes 0, 0.5, 1
  SDS <f 4 f 4 SDS cut off level before age e 5 -1, -1.3, -1.5, -2, -2.5, -3, -3.5
  For ages e 5 to 2.5 years, refer if SDS <f 5 f 5 SDS cut off level after age e 5 -1, -1.3, -1.5, -2, -2.5, -3
Parental height corrected rule For ages e 6 to 2.5 years, refer if e 6 Age (in years) after which the rule is effective 0, 0.5, 1
  length SDS <f 6, AND f 6 Length SDS must lie below this cut off level -1, -1.3, -1.5, -2, -2.5
  length SDS – TH SDS <g 5 g 5 Difference between length SDS and target height (TH) SDS -1, -1.3, -1.5, -2, -2.5
Parental height deflection rule For ages e 7 to 2.5 years, refer if e 7 Age (in years) after which the rule is effective 0, 0.5, 1
  (length SDS2 – length SDS1) <g 6, AND | length SDS2 – TH SDS | > | length SDS1 – TH SDS | g 6 Change in length SDS Length SDS at age X1 is closer to it's target height than length SDS at age X2 -0.5,-1,-1.5,-2,-2.5,-3
Combined weight and length deflection rule For ages e 8 to 2.5 years, AND e 8 Age (in years) after which the rule is effective 0, 0.5, 1
  (weight SDS2 – weight SDS1) <g 7, AND g 7 Weight change in SDS -0.25,-0.5,-1,-1.5,-2
  (length SDS2 – length SDS1) <g 8, AND Y1 > X1 g 8 Length change in SDS Starting point length deflection (Y1) after starting point weight deflection (X1) -0.25,-0.5,-1,-1.5,-2
  1. Several screening rules for growth were studied. Each screening rule consists of parameters that we have varied. For more details, see the paragraph screening rules.
  2. * Calculated for length (height), weight, and BMI
  3. ^For example, if e 1 = 0.5 year and g 1 = -2 weight SDS, then a child is referred if the second weight SDS measurement is -2 below the first weight SDS measurement and both weights were measured after six months of age (or at six months of age for the first measurement).