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Table 3 Simulation values and the percentage of detected CD children (sensitivity) with approximately 2% false-positives (= 98% specificity)

From: Screening rules for growth to detect celiac disease: A case-control simulation study

(symptomatic) CD

Simulation values*

Sensitivity (95%-CI)

100-Specificity (95%-CI)

PPV

BMI extended delta rule

e 2 = 0

f 1 = -1.5

g 2 = -2.5

30 (20–40)

1.9 (1.3–2.5)

0.85%

BMI delta rule

e 1 = 0.5

 

g 1 = -1.5

27 (16–38)

1.9 (1.3–2.5)

0.76%

Slowed growth for BMI rule

e 3 = 0

f 2 = -2

g 3 = -2.5

22 (11–33)

1.8 (1.2–2.4)

0.65%

Conditional weight gain rule

e 4 = 0.5

f 3 = -2.5

g 4 = -0.5 to -1.5

21 (12–30)

1.9 (1.3–2.5)

0.58%

  1. *Table 1 explains the interpretation of the simulation values