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Table 5 Multivariate analysis of the association between factors recorded in birth records and acute lymphoblastic leukemia.*+

From: Parental and infant characteristics and childhood leukemia in Minnesota

 

Sub-cohort

Cases

  
 

No. (%)

No. (%)

HR

95% CI

Maternal age (continuous/5 year increase)

7230

481

0.97

0.88–1.08

Maternal Ethnicity

    

   black

280 (4)

8 (2)

0.43

0.21–0.88

   other/unknown

340 (5)

21 (4)

0.95

0.59–1.51

   white

6610 (91)

452 (94)

 

ref.

Maternal Education

    

   high school

2651 (37)

160 (33)

 

ref.

   <high school

740 (10)

46 (10)

1.11

0.77–1.58

   >high school

3839 (53)

275 (57)

1.18

0.95–1.47

Last live birth interval

    

   no live births

2915 (40)

183 (38)

 

ref.

   <3 years

2783 (38)

172 (36)

1.00

0.80–1.25

   ≥3 years

1532 (21)

126 (26)

1.36

1.05–1.76

Child gender

    

   female

3514 (49)

187 (39)

 

ref.

   male

3716 (51)

294 (61)

1.43

1.18–1.74

Birth weight percentile

    

   < 5th (< 2495 g)

320 (4)

25 (5)

1.37

0.80–2.34

   5th-25th (2496–3117 g)

1436 (20)

71 (15)

 

ref.

   26th-50th (3118–3458 g)

1811 (25)

105 (22)

1.17

0.85–1.60

   51st-75th (3459–3798 g)

1797 (25)

130 (27)

1.37

1.00–1.86

   76th-95th (3799–4309 g)

1510 (21)

115 (24)

1.40

1.02–1.92

   ≥95th (≥ 4309 g)

356 (5)

35 (7)

1.71

1.11–2.65

One minute Apgar score

    

   0–7

1681 (23)

138 (29)

1.30

1.05–1.61

   >7

5549 (77)

343 (71)

 

ref.

  1. *All variables are mutually adjusted for each other, gestational age, and birth year.
  2. +Excludes 1599 individuals with missing data or who were born prior to 1980 (the earliest year gestational age was recorded in birth records).