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Table 1 Pediatric cases of RDD with involvement of salivary glands

From: Unusual presentation of Rosai-Dorfman disease in a 14-month-old Italian child: a case report and review of the literature

Age/sex

Clinical picture at presentation

Main lesion location

Systemic symptoms and/or abnormal blood tests at presentation

Nodal and extranodal involvement

Therapy and clinical evolution

Outcome

Ref.

10/M

Painless masses around parotid and submandibular glands.

Parotid and submandibular glands bilaterally.

None

Apparently both nodal and extranodal

None

Symptom-free

[21]

9/M

Masses around submandibular glands

Submandibular glands bilaterally.

None

Apparently both nodal and extranodal

None

Symptom-free

[21]

11/M

1 year history of painless bilateral neck swelling.

Submandibular and parotid glands bilaterally.

None

Both nodal and extranodal

Surgery

Not reported

[18]

17/F

Bilateral parotid enlargement and cervical lumps localized in the submandibular region.

Mass at left common carotid artery, descending aorta down to the renal artery; MRI finding of bilateral lesions in knee and ankle.

High CRP and ESR, hypergammaglobulinemia.

Both nodal and extranodal

None

Not reported

[19]

12/F

1-month history of enlarging and painless submandibular lymphadenopathy.

Parotid and submandibular glands.

Recurrent fever 2 months before presentation; high ESR.

Nodal

None

No recurrence after 28 month of follow-up.

[28]