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Table 4 Monte Carlo simulations of vancomycin doses needed for 80% probability of target attainment of AUC/MIC > 400 at MIC distribution of CoNS isolates and at fixed MIC values

From: Coagulase negative staphylococcal sepsis in neonates: do we need to adapt vancomycin dose or target?

PMA

MIC 4

MIC 2

MIC 1

Hospital MIC

Dose

Ctrough

Dose

Ctrough

Dose

Ctrough

Dose

Ctrough

24

32.5

41.0

18.5

23.4

11.0

13.9

14.5

18.4

25

35.5

40.6

20.0

22.9

11.5

13.2

16.0

18.3

26

36.0

39.2

20.5

22.4

12.0

13.1

16.5

18.0

27

38.5

37.8

22.0

21.7

13.0

12.8

17.5

17.2

28

41.0

36.6

23.5

21.0

13.5

12.0

18.5

16.5

29

44.0

36.3

24.5

20.2

14.0

11.6

19.5

16.1

30

44.5

34.2

25.5

19.6

15.0

11.5

20.5

15.8

34

49.5

32.3

28.0

18.3

16.5

10.9

22.5

14.8

40

58.5

28.7

33.5

16.4

19.0

9.3

26.5

13.0

  1. PMA (postmenstrual age in weeks)
  2. Ctrough (steady state vancomycin through plasma concentration in mg/L)
  3. Dose (mean administered vancomycin dose in mg/kg/24 h)
  4. MIC (fixed vancomycin MIC value in mg/L)
  5. Hospital MIC (vancomycin MIC distribution of CoNS isolates in our hospital in mg/L)