Transcapillary fluid flux and inflammatory response during neonatal therapeutic hypothermia: an open, longitudinal, observational study

Guthe, Hans Jørgen Timm; Nedrebø, Torbjørn; Damås, Jan Kristian; Wiig, Helge; Berg, Ansgar

doi:10.1186/s12887-018-1020-3

Table 4 Measured cytokines in serum and interstitial fluid throughout therapeutic hypothermia

From: Transcapillary fluid flux and inflammatory response during neonatal therapeutic hypothermia: an open, longitudinal, observational study

Cytokines		Therapeutic Hypothermia, hours after birth
Cytokines		7 h	13 h	25 h	49 h	73 h	Significance
IFN-γ (pg/ml)	Serum	26 ± 25	5 ± 65	NM	NM	NM
IFN-γ (pg/ml)	IF	24 ± 18	3 ± 25	39 ± 36	47 ± 59	28 ± 25	NS
IL-1α (pg/ml)	Serum	119 ± 41	287 ± 501	300 ± 280	246 ± 262	958 ± 945	NS
IL-1α (pg/ml)	IF	1840 ± 2034	2387 ± 2719	2652 ± 2682	2562 ± 3006	8845 ± 7055	P < 0.05¹
IL-1RA (pg/ml)	Serum	38,845 ± 29,946	18,663 ± 17,076	8226 ± 9959	7917 ± 10,524	3069 ± 4132	P < 0.05²
IL-1RA (pg/ml)	IF	1966 ± 1219	1141 ± 787	849 ± 1338	751 ± 421	2033 ± 2047	P < 0.05³
IL-6 (pg/ml)	Serum	6441 ± 6935	3343 ± 4747	9419 ± 4747	4204 ± 11,622	4297 ± 11,622	P < 0.05⁴
IL-6 (pg/ml)	IF	1646 ± 2663	742 ± 1098	868 ± 1325	964 ± 232	134 ± 104	NS
IL-8 (pg/ml)	Serum	3733 ± 2641	3025 ± 3590	2648 ± 4248	2059 ± 2567	1940 ± 2570	NS
IL-8 (pg/ml)	IF	678 ± 904	642 ± 904	1192 ± 2628	669 ± 1022	366 ± 534	NS
IL-10 (pg/ml)	Serum	12,519 ± 11,403	5059 ± 9073	557 ± 664	647 ± 1468	327 ± 665	P < 0.05⁵
IL-10 (pg/ml)	IF	NM	NM	NM	NM	NM
IL-12p40 (pg/ml)	Serum	1018 ± 930	1064 ± 1088	1132 ± 1224	836 ± 875	NM	NS
IL-12p40 (pg/ml)	IF	NM	NM	NM	NM	NM
MCP-1α (pg/ml)	Serum	51,752 ± 36,294	52,073 ± 43,265	63,297 ± 49,865	71,682 ± 42,825	54,762 ± 41,092	NS
MCP-1α (pg/ml)	IF	3369 ± 2900	4367 ± 5604	6260 ± 8353	4381 ± 4062	5955 ± 3863	NS
TGFα (pg/ml)	Serum	64 ± 84	74 ± 98	53 ± 59	95 ± 114	73 ± 73	NS
TGFα (pg/ml)	IF	NM	NM	NM	NM	NM
TNFα (pg/ml)	Serum	503 ± 267	444 ± 246	449 ± 233	418 ± 213	505 ± 199	NS
TNFα (pg/ml)	IF	19 ± 11	24 ± 19	24 ± 16	24.3 ± 18	37 ± 17	NS
VEGF (pg/ml)	Serum	4282 ± 3168	5103 ± 3309	1597 ± 1055	2514 ± 1545	3663 ± 1391	NS
VEGF (pg/ml)	IF	1597 ± 1631	2654 ± 3044	717 ± 1071	1465 ± 2305	NM	NS

All values represent mean ± SD. IF Interstitial fluid, NM not measurable, NS no statistical significant difference. ¹Significance between 73 h and all other time points; ²significance between 73 and 49 h and 7 h; ³significance between 25 and 7 h; ⁴significance between 73 and 7 h; ⁵significance between 73, 49, and 25 h and 7 h

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ISSN: 1471-2431

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