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Table 3 Clinical characteristics according to the presence or absence of PH in severe BPD

From: Developmental outcomes of preterm infants with bronchopulmonary dysplasia-associated pulmonary hypertension at 18–24 months of corrected age

 

Severe BPD

 

PH

Non-PH

P-values

(n = 17)

(n = 23)

Gestational age, weeks

25.3 ± 1.4

25.5 ± 1.0

0.470

Birth weight, g

709.5 ± 195.5

744.0 ± 158.6

0.543

Birth weight < 10th percentile for age, n (%)

5 (29.4)

4 (17.4)

0.456

Multiple birth, n (%)

3 (17.6)

14 (60.9)

0.010

Cesarean section, n (%)

12 (70.6)

13 (56.5)

0.512

Perinatal steroids administration, n (%)

13 (76.5)

17 (77.3)

1.000

Chorioamnionitis, n (%)

9 (52.9)

11 (47.8)

0.749

Preeclampsia, n (%)

3 (18.8)

2 (8.7)

0.631

Oligohydramnios, n (%)

4 (23.5)

2 (8.7)

0.373

RDS, n (%)

14 (82.4)

19 (82.6)

1.000

Treated PDA, n (%)

14 (82.4)

18 (78.3)

0.616

Culture proven sepsis, n (%)

9 (52.9)

8 (34.8)

0.251

ROP operation, n (%)

6 (35.3)

14 (60.9)

0.110

NEC operation, n (%)

5 (31.2)

3 (13.0)

0.235

Length of stay, days

115 (94–268)

113 (77–163)

0.448

Respiratory management

 Duration of CV or HFV, days

72 (0–199)

40 (6–148)

0.090

 BPD steroid, n (%)

5 (29.4)

6 (26.1)

1.000

Dexamethasone cumulative dose (mg/kg)

1.80 (1.10–3.23)

1.10 (0.42–3.04)

0.416

 Discharge on oxygen, n (%)

12 (70.6)

15 (65.2)

0.720

 Total extra O2 supplementationa

25,199 (1428–71,095)

20,325 (11,417–46,362)

0.434

 Episodes of hypoxiab

338 (172–1205)

258 (57–696)

0.254

 Episodes of bradycardiac

40 (8–216)

56 (4–169)

0.734

  1. Data are presented as mean ± SD, median and range, or rate
  2. PH pulmonary hypertension, BPD bronchopulmonary dysplasia, RDS respiratory distress syndrome, PDA patent ductus arteriosus, ROP retinopathy of prematurity, NEC necrotizing enterocolitis, CV conventional ventilation, HFV high-frequency ventilation
  3. a Supplemented extra O2 concentration (%) (fraction of inspired O2− 21%)
  4. b Single value or consecutive values of SpO2 < 80% until 36 weeks of postmenstrual age
  5. c Single value or consecutive values of pulse rate < 80 /min until 36 weeks of postmenstrual age