Table 1 Clinical characteristics of study subjects
| Â | All | No Seizure | EEG Seizure | Clinical Seizure | p-value |
|---|---|---|---|---|---|
| Â | 1658 | 947 | 472 | 239 | Â |
Gestational age in weeks Mean (SD) | 38.80 (1.48) | 38.74 (1.49) | 38.97 (1.48) | 39 (1.41) | 0.010* |
Birth weight in grams Median [IQR] | 3290 [2940, 3700] | 3295 [2940, 3715] | 3270 [2890, 3635] | 3310 [3000, 3720] | 0.206 |
Female sex (n, %) | 721 (43.5) | 395 (41.7) | 223 (47.3) | 103 (43.1) | 0.139 |
Maternal race (n, %) | Â | Â | Â | Â | 0.007* |
 White | 996 (60.1) | 569 (60.1) | 289 (61.2) | 138 (57.7) |  |
 Black | 350 (21.1) | 217 (22.9) | 92 (19.5) | 41 (17.2) |  |
 Asian | 72 (4.3) | 43 (4.5) | 20 (4.2) | 9 (3.8) |  |
 Other | 164 (9.9) | 73 (7.7) | 51 (10.8) | 40 (16.7) |  |
Delivery type (n, %) | Â | Â | Â | Â | 0.862 |
 Cesarean | 1069 (64.5) | 617 (65.2) | 301 (63.8) | 151 (63.2) |  |
 Vaginal, non-operative | 407 (24.6) | 223 (23.6) | 120 (25.4) | 64 (26.8) |  |
 Vaginal, operative | 175(10.6) | 102 (10.8) | 49 (10.4) | 24 (10.0) |  |
 Unknown | 7 (0.42) | 5 (0.53) | 2 (0.42) | 0(0) |  |
Apgar score < = 5 |  |  |  |  |  |
 5 min Median [IQR] | 3 [1,4] | 3 [2,4] | 2 [1,4] | 2 [1,4] | <0.001* |
 10 min Median [IQR] | 3 [2,5] | 4 [2,5] | 3 [2,4] | 3 [1,4] | <0.001* |
 15 min Median [IQR] | 3 [2,5] | 4 [2,5] | 3 [2,4] | 2 [1,4] | 0.012* |
DR resuscitation | |||||
 ETT/Ventilation (n, %) | 1190 (71.8) | 631 (66.6) | 375 (79.5) | 184 (77.0) | <0.001* |
 Chest compressions (n, %) | 688 (41.5) | 319 (33.7) | 238 (50.4) | 131 (54.8) | <0.001* |
 Epinephrine (n, %) | 375 (22.6) | 156 (16.5) | 144 (30.5) | 75 (31.4) | <0.001* |
Presenting pH♯ Median [IQR] | 6.99 [6.82, 7.14] | 7.02 [6.88, 7.15] | 6.96 [6.80, 7.12] | 6.9 [6.80, 7.10] | 0.001* |
Presenting BD Median [IQR] | 16 [11.5, 21] | 15 [11.5, 18.8] | 17 [12, 22.3] | 17.9 [13.3, 24.8] | 0.001* |
Perinatal sentinel event | |||||
 Nuchal cord (n, %) | 288 (17.4) | 174 (18.4) | 79 (16.7) | 35 (14.6) | 0.36 |
 Cord prolapse (n, %) | 54 (3.3) | 31 (3.3) | 11 (2.3) | 12 (5.0) | 0.16 |
 Uterine rupture (n, %) | 96 (5.8) | 46 (4.9) | 34 (7.2) | 16 (6.7) | 0.17 |
 Placental abruption (n, %) | 196 (11.8) | 99 (10.5) | 67 (14.2) | 30 (12.6) | 0.11 |
 Fetal distress (n, %) | 362 (21.8) | 232 (24.5) | 91 (19.3) | 39 (16.3) | 0.007* |
Continuous inotropes on transport/admission (n, %) | 318 (19.2) | 150 (15.8) | 116 (24.6) | 52 (21.8) | < 0.001* |
Maternal antenatal conditions | |||||
 Chorioamnionitis (n, %) | 140 (8.4) | 78 (8.24) | 49 (10.4) | 13 (5.4) | 0.08 |
 Diabetes (n, %) | 198 (11.9) | 126 (13.3) | 36 (7.6) | 36 (15.1) | 0.002* |
Encephalopathy severity+ | Â | Â | Â | Â | <0.001* |
 Mild (n, %) | 308 (18.6) | 261 (27.6) | 29 (6.1) | 18 (7.5) |  |
 Moderate (n, %) | 917 (55.3) | 560 (59.1) | 227 (48.1) | 130 (54.4) |  |
 Severe (n, %) | 433 (26.1) | 126 (13.3) | 216 (45.8) | 91 (38.1) |  |
Type of cooling | Â | Â | Â | Â | <0.001* |
 Head (n, %) | 337 (20.3) | 121 (12.8) | 153 (32.4) | 63 (26.4) |  |
 Whole body (n, %) | 1326 (80.0) | 834 (88.1) | 320 (67.8) | 172 (72.0) |  |
ECMO | 57 (3.4) | 37 (3.9) | 10 (2.1) | 10 (4.2) | 0.17 |
iNO | 334 (20.14) | 182 (19.2) | 90 (19.07) | 62 (25.9) | 0.05 |
Pre-discharge mortality (n, %) | 223 (13.5) | 85 (9.0) | 93 (19.7) | 45 (18.8) | <0.001* |
Survivors hospital LOS Median [IQR] | 13 [10, 22] | 11 [8, 18] | 15 [10, 25.5] | 14 [9, 26] | <0.001* |
Treated with AED (n, %) | 757 (45.6) | 133 (11.9) | 447 (94.7) | 197 (82.4) | <0.001* |
Discharged on AED (n, %) | 261 (20.1) | 11 (1.42) | 196 (56.3) | 54 (30.7) | <0.001* |