Table 1 Characteristics of 209 infants with early-onset neonatal invasive infection between 1997 and 2017 according to gestational age. Comparison between period 1 (1997–2007) and period 2 (2008–2017)
Gestational age (weeks) | |||||
|---|---|---|---|---|---|
Time period | < 28 | 28–36 | ≥ 37 | Total | |
Birth weight (g) (Mean (CI)) | 1997–2017 | 781 (712–850) | 1992 (1804–2180) | 3638 (3533–3744) | 2660 (2487–2832) |
Period 1 (1997–2007) | 770 (644–896) | 2101 (1850–2353) | 3644 (3509–3778) | 2874 (2663–3085) | |
Period 2 (2008–2017) | 786 (698–875) | 1816 (1527–2104) | 3629 (3453–3806) | 2376 (2095–2658) | |
p-value | 1 | 0.1 | 0.3 | 0.004 | |
Gender Male / Female n (%) | 1997–2017 | 17 (46) / 20 (54) | 33 (55) / 27 (45) | 59 (53) / 53 (47) | 109 (52) / 100 (48) |
Period 1 (1997–2007) | 6 (50) / 6 (50) | 21 (57) / 16 (43) | 39 (56) / 31 (44) | 66 (55) / 53 (45) | |
Period 2 (2008–2017) | 11 (44) / 14 (56) | 12 (52) / 11 (48) | 20 (48) / 22 (52) | 43 (48) / 47 (52) | |
p-value | 1 | 0.8 | 0.4 | 0.3 | |
PPROMa n (%) | 1997–2017 | 5 (14) | 15 (25) | 13 (12) | 33 (16) |
Period 1 (1997–2007) | 3 (25) | 10 (27) | 10 (14) | 23 (19) | |
Period 2 (2008–2017) | 2 (8) | 5 (22) | 3 (7) | 10 (11) | |
p-value | 0.3 | 0.8 | 0.4 | 0.1 | |
Caeserean section n (%) | 1997–2017 | 20 (54) | 27 (45) | 28 (25) | 75 (36) |
Period 1 (1997–2007) | 4 (33) | 14 (38) | 20 (29) | 38 (32) | |
Period 2 (2008–2017) | 16 (64) | 13 (57) | 8 (19) | 37 (41) | |
p-value | 0.2 | 0.2 | 0.4 | 0.2 | |
Febrile mother n (%) | 1997–2017 | 8 (22) | 15 (25) | 23 (21) | 46 (22) |
Period 1 (1997–2007) | 3 (25) | 10 (27) | 12 (17) | 25 (21) | |
Period 2 (2008–2017) | 5 (20) | 5 (22) | 11 (26) | 21 (23) | |
p-value | 1 | 0.8 | 0.3 | 0.7 | |
Neonatal Distress Apgar < 7, n (%) | |||||
at 5 min | 1997–2017 | 15 (41) | 11 (18) | 10 (9) | 36 (17) |
Period 1 (1997–2007) | 3 (25) | 7 (19) | 6 (9) | 16 (13) | |
Period 2 (2008–2017) | 12 (48) | 4 (17) | 4 (10) | 20 (22) | |
p-value | 0.3 | 1 | 1 | 0.1 | |
at 10 min | 1997–2017 | 6 (16) | 2 (3) | 3 (3) | 11 (5) |
Period 1 (1997–2007) | 3 (25) | 1 (3) | 2 (3) | 6 (5) | |
Period 2 (2008–2017) | 3 (12) | 1 (4) | 1 (2) | 5 (6) | |
p-value | 0.4 | 1 | 1 | 1 | |
Fatal cases n (%) | 1997–2017 | 8 (22) | 5 (8) | 2 (2) | 15 (7) |
Period 1 (1997–2007) | 4 (33) | 2 (5) | 2 (3) | 8 (7) | |
Period 2 (2008–2017) | 4 (16 | 3 (13) | 0 | 7 (8) | |
p-value | 0.4 | 0.3 | 0.5 | 0.8 | |
Total n (%) | 1997–2017 | 37 (18) | 60 (29) | 112 (54) | 209 (100) |
Period 1 (1997–2007) | 12 (10) | 37 (31) | 70 (59) | 119 (100) | |
Period 2 (2008–2017) | 25 (28) | 23 (26) | 42 (47) | 90 (100) | |
p-value | 0.002 | 0.4 | 0.09 | ||