Fig. 1
From: Genotype–phenotype correlation in two Polish neonates with alveolar capillary dysplasia
Histopathological examination of lung samples showing characteristic features of ACDMPV. Haematoxylin and eosin staining (H&E) of lung tissue obtained post-mortem showing abnormal shunt vessels (arrows) in the bronchovascular bundle and diffuse thickening of inter-alveolar septa with reduced density of capillaries. Immunostaining for the endothelial markers CD 31 and CD34 highlights poor approximation of the alveolar capillaries to epithelial cells and marked congestion compared to control lung from a term infant. As a result, the air-blood barrier was disrupted. H&E: a) patient 1, b) patient 2; CD31: c) control, d) patient 1, e) patient 2; CD34: f) control, g) patient 1, h) patient 2