Phenylketonuria screening in Iranian newborns: a systematic review and meta-analysis

Shokri, Mehdi; Karimi, Parviz; Zamanifar, Hadis; Kazemi, Fatemeh; Badfar, Gholamreza; Azami, Milad

doi:10.1186/s12887-020-02230-6

BMC Pediatrics

Table 1 Summary of characteristics in studies into a meta-analysis

From: Phenylketonuria screening in Iranian newborns: a systematic review and meta-analysis

Ref	First author, Published Year	Year	Place	Design	Age (day)	Method	Sample size			Suspected HPA^a	PKU^b	Classic PKU	HPA	Quality
							Female	Male	All
[14]	Senemar S, 2009	2000–5	Fars	Screening program	3	Fluorometric			70,477		15	2	13	Medium risk
[15]	Habib A, 2010	2004–7	Fars	Screening program	3–5	Colorimetric and HPLC	87,091	88,143	175,235	30	28			Medium risk
[16]	Abbaskhanian A, 2017	2007–2015	Mazandaran	Screening program	3–5	Colorimetric method and HPLC technique	193,229	214,015	407,244					Medium risk
[16]	Abbaskhanian A, 2017	2007	Mazandaran	Screening program	3–5	Colorimetric method and HPLC technique	20,759	21,569	42,328	254	2	1	1	Medium risk
[16]	Abbaskhanian A, 2017	2008	Mazandaran	Screening program	3–5	Colorimetric method and HPLC technique	22,506	23,197	45,703	66	2	0	2	Medium risk
[16]	Abbaskhanian A, 2017	2009	Mazandaran	Screening program	3–5	Colorimetric method and HPLC technique	22,050	23,392	45,442	92	7	1	6	Low risk
[16]	Abbaskhanian A, 2017	2010	Mazandaran	Screening program	3–5	Colorimetric method and HPLC technique	21,447	22,973	44,420	19	3	1	2	Medium risk
[16]	Abbaskhanian A, 2017	2011	Mazandaran	Screening program	3–5	Colorimetric method and HPLC technique	21,168	23,374	44,342	11	1	0	1	Low risk
[16]	Abbaskhanian A, 2017	2012	Mazandaran	Screening program	3–5	Colorimetric method and HPLC technique	21,719	22,633	44,352	7	2	1	1	Medium risk
[16]	Abbaskhanian A, 2017	2013	Mazandaran	Screening program	3–5	Colorimetric method and HPLC technique	22,738	23,256	45,994	5	3	0	3	Low risk
[16]	Abbaskhanian A, 2017	2014	Mazandaran	Screening program	3–5	Colorimetric method and HPLC technique	22,672	24,548	47,220	6	4	1	3	Medium risk
[16]	Abbaskhanian A, 2017	2015	Mazandaran	Screening program	3–5	Colorimetric method and HPLC technique	23,181	24,262	47,443	5	3	1	2	Low risk
[17]	Ordooei M, 2015	2010–11	Yazd	Screening program	3	Colorimetric method and HPLC technique			22,131		4	1	3	Medium risk
[18]	Motamedi N, 2017	2006	Lorestan	Screening program	Infancy	Colorimetric, ELISA and HPLC technique			33,284		4			Medium risk
[18]	Motamedi N, 2017	2007	Lorestan	Screening program	Infancy	Colorimetric, ELISA and HPLC technique			33,890		5			Medium risk
[18]	Motamedi N, 2017	2008	Lorestan	Screening program	Infancy	Colorimetric, ELISA and HPLC technique			34,045		7			Medium risk
[18]	Motamedi N, 2017	2009	Lorestan	Screening program	Infancy	Colorimetric, ELISA and HPLC technique			35,969		5			Medium risk
[18]	Motamedi N, 2017	2010	Lorestan	Screening program	Infancy	Colorimetric, ELISA and HPLC technique			35,011		6			Medium risk
[18]	Motamedi N, 2017	2011	Lorestan	Screening program	Infancy	Colorimetric, ELISA and HPLC technique			35,799		10			Medium risk
[18]	Motamedi N, 2017	2012	Lorestan	Screening program	Infancy	Colorimetric, ELISA and HPLC technique			37,154		6			Low risk
[18]	Motamedi N, 2017	2013	Lorestan	Screening program	Infancy	Colorimetric, ELISA and HPLC technique			37,944		4			Medium risk
[18]	Motamedi N, 2017	2014	Lorestan	Screening program	Infancy	Colorimetric, ELISA and HPLC technique			39,388		15			Low risk
[18]	Motamedi N, 2017	2015	Lorestan	Screening program	Infancy	Colorimetric, ELISA and HPLC technique			38,585		5			Medium risk
[18]	Motamedi N, 2017	2016	Lorestan	Screening program	Infancy	Colorimetric, ELISA and HPLC technique			36,585		7			Low risk
[19]	Ajami A, 2013	2012–13	Isfahan	Screening program	Infancy	Colorimetric method and HPLC technique			77,000		45	12	33	Medium risk
[20]	Nasiri Sh, 2013	2012–13	South Khorasan	Screening program	3	Colorimetric method and HPLC technique			26,455	31	23			Low risk
[21]	Modares Sadrani N, 2013	2012–13	Ardebil	Screening program	3	Colorimetric method and HPLC technique			44,232		13	8	5	Medium risk
[22]	Morovatdar N, 2015	2013	Razavi Khorasan	Screening program	Infancy	Colorimetric method and HPLC technique			69,347		4			Medium risk
[23]	Saadatinasab Z, 2015	2012–14	South Khorasan	Screening program	Neonatal	Colorimetric method and HPLC technique			30,103	55	3			Medium risk
[24]	Badiee M, 2014	2011–13	Torbat Heydariy	Screening program	Neonatal	Colorimetric method and HPLC technique	5390	5701	11,091		16	1	15	Medium risk
[25]	Karamifar H, 2010	2007–8	Fars	Screening program	3–5	Colorimetric method and HPLC technique	35,470	41,496	76,966	9	8	3	5	Medium risk
[26]	Soori M, 2018	2016–17	Nahavand	Screening program	Neonatal	Immuno-enzymatic method			5704	0	0	0	0	Medium risk
[27]	Heydari A, 2016	2013	All Iran	Screening program	Neonatal	Colorimetric method and HPLC technique			1,356,132		322			Medium risk
[28]	Ganji F, 2018	2012	Chaharmahal and Bakhtiari	Screening program	1–5	Colorimetric method and HPLC technique			13,022		1			Low risk
[28]	Ganji F, 2018	2013	Chaharmahal and Bakhtiari	Screening program	1–5	Colorimetric method and HPLC technique			19,612		4			Medium risk
[28]	Ganji F, 2018	2014	Chaharmahal and Bakhtiari	Screening program	1–5	Colorimetric method and HPLC technique			19,753		3			Low risk
[28]	Ganji F, 2018	2015	Chaharmahal and Bakhtiari	Screening program	1–5	Colorimetric method and HPLC technique			20,893		3			Medium risk
[29]	Mahmoodi M, 2013	2012–13	Golestan	Screening program	Neonatal	Colorimetric method and HPLC technique			74,000	32	4			Low risk
[30]	Behineh M, 2015	2007–2014	Khonj	Screening program	3–5	Fluorometric			6399		2			Medium risk
[31]	Rezabigidavarani E, 2018	2012–2016	Kerman	Screening program	At birth	Colorimetric method and HPLC technique			77,467	85	15	2	13	Low risk

^a hyperphenylalaninemia
^b Phenylketonuria

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ISSN: 1471-2431

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