From: A modified Delphi to define drug dosing errors in pediatric critical care
Proportion of agreement (%) Round agreement achieved | |
---|---|
YES, DEFINITELY constitutes a dosing error | |
Dosing a drug above reference range, but the drug dose was intercepted (near-miss) and did not reach patient | 76 Round 1 |
Dosing a drug below the minimum recommended dose, when the drug is possibly life-saving | 73 Round 2 |
YES, PROBABLY constitutes a dosing error | |
Dosing a drug in a dose that is predicted to give serum levels below desired therapeutic range (e.g. 50% below lower limit target) | 62 Round 2 |
Dosing a drug by weight, without accounting for a significant drug interaction | 68 Round 3 |
Dosing a drug in a dose that is likely to give serum levels above desired therapeutic range (e.g. 50% above upper limit target) | 60 Round 2 |
MAY or MAY NOT be a dosing Error | |
Dosing a drug by weight, without adjusting for age | 76 Round 2 |
Dosing a drug by weight, without accounting for body surface area | 73 Round 1 |
Dosing a drug dose above the maximum dose recommended in the hospital formulary, guideline or reference sources | 66 Round 2 |
Dosing a drug above the maximum recommended dose, in a patient who is in end-of life care | 71 Round 2 |
Dosing a drug above the maximum recommended dose in a patient who is on ECMOb | 82 Round 2 |
Dosing a drug above the maximum recommended dose, when the drug is possibly life-saving (e.g. antibiotics in sepsis) | 60 Round 2 |
Dosing a drug by weight, without adjusting for renal insufficiency (Creatinine 50% higher than baseline) | 69 Round 3 |
NO, UNLIKELY to constitute a dosing error | |
Dosing a drug dose that cannot easily be administered using dosage forms available | 66 Round 2 |
NO, DEFINITELY NOT a dosing error | |
None | |
Dosing a drug at a dose where the patient has had a previous severe adverse event | Partial agreementc |
Dosing a drug for which the use is off-label in children (i.e. prescribed for a condition that it is not officially approved for) | Partial agreementd |