Table 1 Characteristics of neonates treated with combination therapy (Moxifloxacin and another antibiotic) for Mycoplasma Hominis CNS infection
From: Mycoplasma hominis meningitis in an extremely preterm newborn: a case report
Gestational Age | Age at presentation | Clinical presentation | Confirmation of diagnosis | Empirical antibiotic therapy and duration | Antibiotics for Mycoplasma Hominis | Outcome | |
|---|---|---|---|---|---|---|---|
Hata and colleagues3 | 38 weeks | 25 days | Fever, vomiting, focal seizures | 16S RNA PCR | Ampicillin & Cefotaxime (day 1–2) Ciprofloxacin (day 6–17) Acyclovir (day 6–8) Chloramphenicol (day 8–17) | Minocycline for 28 days (day 6–34) Moxifloxacin for 17 days (day 17–34) | Recovery with left hemiplegia |
Watt and colleagues5 | 26 weeks | 7 days | Apnea, hypotonia, generalized seizures | 16S RNA PCR | Ampicillin and Gentamycin (day1-8) Ceftazidime (day 1–5 ) Vancomycin (day 8–19 ) Acyclovir (day 8–19) Meropenem (day 12–19 ) | Doxycycline for 6 weeks (day 19–60) Moxifloxacin for 6 weeks (day 19–60) | Recovery, neurological outcomes not reported |
Our case | 25 + 6 weeks | 7 days | Lethargy, tachycardia, generalized seizures | 16S RNA PCR | Ampicillin and Gentamycin (day 1–2) Azithromycin (day 3–6) Vancomycin and cefotaxime (day 7–10) | Doxycycline for 6 weeks (day 10–52) Moxifloxacin for 6 weeks (day 10–52) | Recovery with normal neurological examination at discharge, follow up at 6 months showed normal neurological examination |