Table 1 Laboratory findings on initial presentation and at time of sHLH diagnosis
Laboratory test | At the diagnosis of WD (3 months old) | At the diagnosis of HLH (4 months old) | Normal reference |
|---|---|---|---|
WBC | 6.9 | 4.6 | 5.5–18 × 103/µL |
ANC | 3.0 | 3.2 | 1.0–9.5 × 103/µL |
ALC | 2.9 | 1.6 | 2–17 × 103/µL |
Hemoglobin | 6.7 | 6.6 | 10.1–14.4 g/dL |
Platelets count | 323 | 39 | 150–450 × 109/L |
Fibrinogen | NA | 1.6 | 0.9 |
ALP | 153 | 295 | 122–469 U/L |
ALT | 28 | 229 | 5–40 U/L |
AST | NA | 670 | 5–40 U/L |
GGT | NA | 222 | 5–40 U/L |
Albumin | 34 | 30 | 35–55 mg/dL |
Total bilirubin Direct bilirubin | 7 NA | 19 9 | 0.2–1 mg/dL 0.08–0.25 mg/dL |
Serum ferritin | NA | 22,683 | 10–120 ng/mL |
LAL activity on leucocytes | < 0.02 | < 0.02 | 0.37–2.30 nmol/punch/hr |