Table 2 Clinical characteristics of children (2–9 years) and adolescents (10–18 years) with beta thalassemia
Children (N = 39) | Adolescents (N = 71 ) | Total (N = 110) | ||||
|---|---|---|---|---|---|---|
n | % | n | % | n | % | |
Diagnosis | ||||||
BTM | 39 | 100.0 | 66 | 100.0 | 105 | 100.0 |
Hemoglobin ; Mean (sd) | 9.69 (0.829) | 9.90 (0.986) | 9.83 (0.934) | |||
Hemoglobin group | ||||||
< 9 gm% | 4 | 10.8 | 7 | 10.6 | 11 | 10.7 |
≥ 9 gm% | 33 | 89.2 | 59 | 89.4 | 92 | 89.3 |
Ferritin ; Median (Q1-Q3) | 2213 (1636–3181) | 2521 (1621–3789) | 2361 (1644–3725) | |||
Fasting Glucose | ||||||
< 100 mg/dL | - | - | 34 | 73.9 | 34 | 73.9 |
100 - < 126 mg/dL | - | - | 12 | 26.1 | 12 | 26.1 |
≥ 126 mg/dL | - | - | 0 | 0.0 | 0 | 0.0 |
TSH (uIU/ml) | ||||||
0.3–4.2 | 29 | 85.3 | 57 | 91.9 | 86 | 89.6 |
> 4.2 | 5 | 14.7 | 5 | 8.1 | 10 | 10.4 |
FT4 | ||||||
< 12.0 | 1 | 2.9 | 1 | 1.5 | 2 | 2.0 |
12–23 | 33 | 97.1 | 64 | 98.5 | 97 | 98.0 |
Transfusion - Time of Initiation | ||||||
Days; Median (Q1 – Q3) | 244 (182–455) | 273 (120–1119) | 260 (136–929) | |||
Years; Median (Q1 – Q3) | 0.67 (0.50–1.24) | 0.71 (0.31–3.03) | 0.68 (0.35–2.54) | |||
Number of Transfusions per year | ||||||
Q3-4 W | 5 | 27.8 | 6 | 9.8 | 11 | 13.9 |
Q3W | 13 | 72.2 | 51 | 83.6 | 64 | 81.0 |
Q4W | - | - | 3 | 4.9 | 3 | 3.8 |
Q6W | - | - | 1 | 1.6 | 1 | 1.3 |
Drug of Chelation | ||||||
DFO (Deferoxamine) | 11 | 28.2 | 6* | 9.1 | 17 | 16.2 |
DFP (Deferiprone) | 1 | 2.6 | 4* | 6.1 | 5 | 4.8 |
DFX (Deferasirox) | 26 | 66.7 | 60* | 90.9 | 86 | 81.9 |