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General pediatric medicine and surgery

This section considers studies of general medicine and surgical intervention in children and adolescents.

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  2. Hydatid disease is an endemic disease in many countries of the world including the Middle East. It mainly affects the liver and lungs. Intramuscular hydatid disease is rarely reported in children. Such uncommo...

    Authors: Ruba A. Khasawneh, Ziyad M. Mohaidat, Rawand A. Khasawneh, Sohaib B. Zoghoul and Yousef M. Henawi

    Citation: BMC Pediatrics 2021 21:371

    Content type: Case report

    Published on:

  3. Spinal cord compression (SCC) is an uncommon, severe complication of Hodgkin lymphoma (HL), occurring in 0.2% of cases at the onset and in 6% during disease progression. We present a teenager with SCC with cli...

    Authors: Giulia Salomone, Milena La Spina, Giuseppe Belfiore, Gregoria Bertuna, Laura Cannavò, Stefano Catanzaro, Salvatore D’Amico, Mariaclaudia Meli, Andrea Musumeci, Lucia Salvatorelli, Maria Grazia Scuderi, Corrado Spatola, Mariella Valenzise, Andrea Di Cataldo and Giovanna Russo

    Citation: BMC Pediatrics 2021 21:358

    Content type: Case report

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  4. Salmonella infection presents itself in a wide variety of ways, ranging from mild self-limited illness to severe systemic disease with multiorgan involvement. Acute pancreatitis (AP) is a very rare complication t...

    Authors: Salwa Al Kaabi, Aysha Al Kaabi and Hasa Al Nuaimi

    Citation: BMC Pediatrics 2021 21:353

    Content type: Case report

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  5. Neonates and small infants with congenital cardiac disease undergoing cardiac surgery represent major challenges facing paediatric anaesthesia and perioperative medicine. Aims.

    Authors: Judith Schiefer, Paul Lichtenegger, Daniel Zimpfer, Doris Hutschala, Lorenz Kuessel, Alessia Felli, Stephan Hornykewycz, Peter Faybik and Eva Base

    Citation: BMC Pediatrics 2021 21:341

    Content type: Research article

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  6. Perthes disease (Legg-Calvé-Perthes, LCP) is a self-limited and non-systemic disease occurring in the femoral heads of children, which is mainly manifested as an ischemic necrosis of the femoral head epiphysis...

    Authors: Guoming Chen, Tengyu Chen, Peng Zhang, Zhaoping Zhang, Ruilan Huang, Tao Chen, Wei He, Haibin Wang and Chi Zhou

    Citation: BMC Pediatrics 2021 21:339

    Content type: Case report

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  7. SARS-CoV-2 has been found to be exquisitely adept at triggering autoimmunity and multiple new onset autoimmune diseases have been described as a post-infectious complication of COVID-19 infection in the adult ...

    Authors: Daniel D. Reiff, Chloe G. Meyer, Brittany Marlin and Melissa L. Mannion

    Citation: BMC Pediatrics 2021 21:333

    Content type: Case report

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  8. When evaluating speech in children with cleft palate with or without cleft lip (CP/L), children with known syndromes and/or additional malformations (CP/L+) are usually excluded. The aim of this study was to p...

    Authors: Kristina Klintö, Maria Sporre and Magnus Becker

    Citation: BMC Pediatrics 2021 21:309

    Content type: Research article

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  10. Migraine is common in childhood, peaks in adolescents and persists into adulthood in at least 40% of patients. There is need for early interventions to improve the burden of disease and, if possible, reduce ch...

    Authors: Mirjam N. Landgraf, Florian Heinen, Lucia Gerstl, Christine Kainz, Ruth Ruscheweyh, Andreas Straube, Joerg Scheidt, Sabine von Mutius, Viola Obermeier and Ruediger von Kries

    Citation: BMC Pediatrics 2021 21:294

    Content type: Study protocol

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  12. Organ size is influenced by a number of factors. Age, height, weight, and ethnicity are known influencing factors. Pediatric populations have changed over time, puberty beginning earlier resulting in a changin...

    Authors: Stephan Waelti, Tim Fischer, Simon Wildermuth, Sebastian Leschka, Tobias Dietrich, Sabine Guesewell, Pascal Mueller, Michael Ditchfield and Stefan Markart

    Citation: BMC Pediatrics 2021 21:276

    Content type: Research article

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  13. Genome wide gene expression analysis has revealed hints for independent immunological pathways underlying the pathophysiologies of phlegmonous (PA) and gangrenous appendicitis (GA). Methods of artificial intel...

    Authors: Josephine Reismann, Natalie Kiss and Marc Reismann

    Citation: BMC Pediatrics 2021 21:268

    Content type: Research article

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  14. Abdominal pain and other gastrointestinal symptoms are common presenting features of multisystem inflammatory syndrome in children (MIS-C) and can overlap with infectious or inflammatory abdominal conditions, ...

    Authors: Michelle Hwang, Kelsey Wilson, Lisa Wendt, Joshua Pohlman, Emily Densmore, Caitlin Kaeppler, Kyle Van Arendonk and Sarah Yale

    Citation: BMC Pediatrics 2021 21:258

    Content type: Case report

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  15. Racial/ethnic disparities in the use of opioids to treat pain disorders have been previously reported in the emergency department (ED). Further research is needed to better evaluate the impact race/ethnicity m...

    Authors: Michael T. Phan, Daniel M. Tomaszewski, Cody Arbuckle, Sun Yang, Candice Donaldson, Michelle Fortier, Brooke Jenkins, Erik Linstead and Zeev Kain

    Citation: BMC Pediatrics 2021 21:252

    Content type: Research article

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  16. There are few non-invasive monitoring methods that can reliably predict fluid responsiveness (FR) in children. Here, we interrogate the value of doppler ultrasound evaluation of passive leg raising (PLR)-induc...

    Authors: Deqiang Luo, Wei Dai, Lei Lei and Xueying Cai

    Citation: BMC Pediatrics 2021 21:243

    Content type: Research article

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  17. Spinal arteriovenous malformations in children are extremely rare and pose great risk for intraoperative hemorrhage. Congenital syphilis sometimes presents with vascular symptoms, however, there is little publ...

    Authors: Mia J. Bertoli, Kruti Parikh, David Klyde, Catherine A. Mazzola and Shridevi Pandya Shah

    Citation: BMC Pediatrics 2021 21:242

    Content type: Case report

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  18. Neonatal intrahepatic cholestasis caused by citrin deficiency (NICCD) is a common form of neonatal jaundice. Histopathological examination of the liver in patients with NICCD typically shows fatty liver, steat...

    Authors: Ryosuke Miyamoto, Jun Sada, Koki Ota, Kenitiro Kaneko, Hironori Kusano, Yoshiteru Azuma and Akihisa Okumura

    Citation: BMC Pediatrics 2021 21:237

    Content type: Case report

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  19. Alemtuzumab is a T cell depleting antibody agent used as induction immunosuppressant therapy in solid organ transplant recipients. In addition, it is being increasingly used to treat severe or glucocorticoid-r...

    Authors: Nori J. L. Smeets, Ruud J. R. Eijk, Saskia N. de Wildt and Charlotte M. H. H. T. Bootsma-Robroeks

    Citation: BMC Pediatrics 2021 21:229

    Content type: Case report

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  20. Children with acute peripheral facial nerve palsy cannot yet be recommended corticosteroid treatment based on evidence. Adults with idiopathic facial nerve palsy are treated with corticosteroids, according to ...

    Authors: Sofia Karlsson, Sigurdur Arnason, Nermin Hadziosmanovic, Åsa Laestadius, Malou Hultcrantz, Elin Marsk and Barbro H. Skogman

    Citation: BMC Pediatrics 2021 21:220

    Content type: Study protocol

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  23. Ewing’s sarcoma is a common malignant bone tumor in children and young adults. Rarely, extra-skeletal soft tissues and visceral organs can also be the site of origin of Ewing’s sarcoma. Primary pulmonary Ewing...

    Authors: Xuefeng Ling, Jianlin Tong, Liangliang Wang, Chuan Yao and Zhiying Chen

    Citation: BMC Pediatrics 2021 21:194

    Content type: Case report

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  24. HIV is a major contributor to infant mortality. A significant gap remains between the uptake of infant and maternal antiretroviral regimens and only a minority of HIV-exposed infants receives prophylaxis and s...

    Authors: Lilian M. N. Kebaya, Dalton Wamalwa, Nyambura Kariuki, Bashir Admani, Philip Ayieko and Ruth Nduati

    Citation: BMC Pediatrics 2021 21:186

    Content type: Research article

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  25. Characteristics of obstructive sleep apnea (OSA) changes with age. Infants, toddlers and prepubertal children with OSA are usually underweight and may suffer from failure to thrive (FTT). Adenotonsillectomy (T...

    Authors: Keren Nathan, Galit Livnat, Liat Feraru and Giora Pillar

    Citation: BMC Pediatrics 2021 21:184

    Content type: Research article

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  26. The aim of this study was to characterize patients who ingested multiple rare-earth magnets, reveal the harm of rare-earth magnet foreign bodies in the digestive tract, and develop a clinical management algori...

    Authors: Yucan Zheng, Zhihua Zhang, Kunlong Yan, Hongmei Guo, Mei Li, Min Lian and Zhifeng Liu

    Citation: BMC Pediatrics 2021 21:179

    Content type: Research article

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  27. Dental procedures under general anesthesia (DGA) was found to improve the oral health-related quality of children’s life. However, some parents and pediatricians expressed concern about the neurotoxicity of ge...

    Authors: Pinping Zhou, Chao Zhang, Guijin Huang, Yuan Hu, Wenzhu Ma and Cong Yu

    Citation: BMC Pediatrics 2021 21:177

    Content type: Research article

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  30. The aim of the present study was to summarize the clinical characteristics of in children aged under 3 years and analyze the related factors affecting the prognosis.

    Authors: Tian Zhi, Wei-Ling Zhang, Yi Zhang, Hui-Min Hu and Dong-Sheng Huang

    Citation: BMC Pediatrics 2021 21:170

    Content type: Research article

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  31. Homelessness is associated with health problems and with adverse childhood experiences (ACEs). The risk of chronic health conditions for homeless compared to housed youth, and how this risk interacts with ACEs...

    Authors: Andrew J. Barnes, Amy L. Gower, Mollika Sajady and Katherine A. Lingras

    Citation: BMC Pediatrics 2021 21:164

    Content type: Research article

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  32. Lipoblastoma is a rare benign mesenchymal neoplasm of infancy that most commonly occurs on the extremities and trunk but can arise at variable sites of the body. Retroperitoneal lipoblastomas are particularly ...

    Authors: Elena Gerhard-Hartmann, Verena Wiegering, Clemens Benoit, Thomas Meyer, Andreas Rosenwald, Katja Maurus and Karen Ernestus

    Citation: BMC Pediatrics 2021 21:159

    Content type: Case report

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  33. Kawasaki disease (KD) is a form of systemic febrile vasculitis that is complicated with coronary artery lesions (CAL). The tight junctions that maintain the intestinal barrier also play a role in systemic infl...

    Authors: Wan-Tz Lai, Hung-Chang Lee, Ying-Hsien Huang, Mao-Hung Lo and Ho-Chang Kuo

    Citation: BMC Pediatrics 2021 21:157

    Content type: Research article

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  34. Necrotizing enterocolitis (NEC) is a common devastating inflammatory gastrointestinal disease and frequently occurs in premature infants. Here, we reported a case of late-onset NEC in a term neonate with good ...

    Authors: Gunadi, Dian Nirmala Sirait, Aditya Rifqi Fauzi, Ninditya Nugroho, Fadil Fahri, William Widitjiarso, Kristy Iskandar and Nurnaningsih

    Citation: BMC Pediatrics 2021 21:152

    Content type: Case report

    Published on:

  35. In the current study, we applied a combination of non-invasive neuromodulation modalities concurrently with multiple stimulating electrodes. Specifically, we used transcranial pulsed current stimulation (tPCS)...

    Authors: Zhenhuan Liu, Shangsheng Dong, Sandra Zhong, Fang Huang, Chuntao Zhang, Yuan Zhou and Haorong Deng

    Citation: BMC Pediatrics 2021 21:141

    Content type: Research article

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  36. Using effective scolicidal agents intraoperatively is essential to lessen the recurrence rate of hepatic echinococcosis. However, severe hypernatremia may occur after hypertonic saline (HS) has been applied as...

    Authors: Kewei Li, Yijun Liu, Xiaolong Xie, Rongxing Zhou and Bo Xiang

    Citation: BMC Pediatrics 2021 21:140

    Content type: Research article

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  37. Malignant melanoma (MM) arises predominantly after adolescence and is uncommon in children. Congenital MM in newborns is even rarer with a dearth of published literature; as a consequence, there is no uniform ...

    Authors: Jun Zhou, Meng-xing Lv, Ling Duan, Yu-cheng Xie, Zhi-xiang A, Hong-fang Wu and Yan Gao

    Citation: BMC Pediatrics 2021 21:121

    Content type: Case report

    Published on:

  39. Defects of bone marrow mesenchymal stem cells (BM-MSCs) in proliferation and differentiation are involved in the pathophysiology of aplastic anemia (AA). Infusion of umbilical cord mesenchymal stem cells (UC-M...

    Authors: Yang Lan, Fang Liu, Lixian Chang, Lipeng Liu, Yingchi Zhang, Meihui Yi, Yuli Cai, Jing Feng, Zhibo Han, Zhongchao Han and Xiaofan Zhu

    Citation: BMC Pediatrics 2021 21:102

    Content type: Research article

    Published on:

  40. Cornell assessment of pediatric delirium (CAPD) showed advantage in diagnosis of pediatric delirium in Chinese critically ill patients. But its performance in surgical patients is still unclear. The present st...

    Authors: Hong Hong, Chao Guo, Zhi-Hua Liu, Bo-Jie Wang, Shu-Zhe Zhou, Dong-Liang Mu and Dong-Xin Wang

    Citation: BMC Pediatrics 2021 21:87

    Content type: Research article

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  41. As sleep-related difficulties are a growing public health concern, it is important to gain an overview of the specific difficulty areas of the most vulnerable individuals: children. The current descriptive stu...

    Authors: Christiane Lewien, Jon Genuneit, Christof Meigen, Wieland Kiess and Tanja Poulain

    Citation: BMC Pediatrics 2021 21:82

    Content type: Research article

    Published on:

  42. Cognitive abilities like language, memory, reasoning, visualization, and perceptual functioning shape human action and are considered critical to the successful interaction with the environment. Alternatively,...

    Authors: Fidaa Almomani, Murad O. Al-momani, Soha Garadat, Safa Alqudah, Manal Kassab, Shereen Hamadneh, Grant Rauterkus and Richard Gans

    Citation: BMC Pediatrics 2021 21:71

    Content type: Research article

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  43. This study aimed to retrospectively analyze the correlation between congenital abnormality of the urogenital system and various factors in children with neural tube defects (NTDs).

    Authors: Zhi-Hua Hong, Dong-Hui Jin, Xiao-Jian Yuan, Yang Zhao, Hou-Wei Lin and Jie Chen

    Citation: BMC Pediatrics 2021 21:66

    Content type: Research article

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  44. For newborns and infants wearing diapers the difficulties in characterizing the appearance of the stool are significant, since the changes in consistency, quantity, and color of the stool are higher than in ot...

    Authors: Laura Cantisano de Deus Silva, Priscila Monaro Bianchini, Erika Veruska Paiva Ortolan, Juliana Fattori Hamamoto, Rosemary Fermiano, Rebeca Mayara Padilha Rego, João César Lyra, Marc Alexander Benninga and Pedro Luiz Toledo de Arruda Lourenção

    Citation: BMC Pediatrics 2021 21:64

    Content type: Research article

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  45. The effect of biologic therapy on the incidence of inflammatory bowel disease (IBD)-related hospitalizations is controversial. The high efficacy of biologic agents is weighted against potential therapy-related...

    Authors: Gil Berkovitch, Shlomi Cohen, Ronit Lubetzky, Dana Singer and Anat Yerushalmy-Feler

    Citation: BMC Pediatrics 2021 21:63

    Content type: Research article

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  46. Depression in children presents a significant health burden to society and often co-exists with chronic illnesses, such as human immunodeficiency virus (HIV). Research has demonstrated that 10–37% of children ...

    Authors: Agnes Binagwaho, Eric Remera, Alice Uwase Bayingana, Darius Gishoma, Kirstin Woody Scott, Madeline Goosman, Eliza Campbell, Mawuena Agbonyitor, Yvonne Kayiteshonga and Sabin Nsanzimana

    Citation: BMC Pediatrics 2021 21:59

    Content type: Research article

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  47. An Anorectal Malformation (ARM) is a rare congenital malformation, which requires proper correction to ensure the best long-term prognosis. These procedures are relatively infrequent and complex, in which a st...

    Authors: J. A. van Ling, G. M. J. Bökkerink, I. de Blaauw and S. M. B. I. Botden

    Citation: BMC Pediatrics 2021 21:57

    Content type: Technical advance

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  48. We aimed to study the effectiveness of preoperative thyroid hormone levels in predicting intensive care unit (ICU) mortality after cardiopulmonary bypass (CPB) in infants with congenital heart disease (CHD).

    Authors: Di Yu, Liang Zou, Yueshuang Cun, Yaping Li, Qingfeng Wang, Yaqin Shu and Xuming Mo

    Citation: BMC Pediatrics 2021 21:50

    Content type: Research article

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  49. The purpose of this study was to assess scan parameters and to propose strategies to optimize the examinations of children (from 0 to 15 years old) on adult scanners in developing countries.

    Authors: Fotso Eddy Kamdem, Samba Odette Ngano, Clemence Alla Takam, Alain Jervé Fotue, Serge Abogo and Cornellius Lukong Fai

    Citation: BMC Pediatrics 2021 21:44

    Content type: Research article

    Published on:

    The Correction to this article has been published in BMC Pediatrics 2021 21:93

  50. Imerslund-Gräsbeck syndrome is a rare genetic disease characterised by vitamin B12 deficiency and proteinuria.

    Authors: Visvalingam Arunath, Thabitha Jebaseeli Hoole, Asanka Rathnasri, Oshanie Muthukumarana, Ishara Minuri Kumarasiri, Nishadi Dananjani Liyanage, Yasintha Costa and Sachith Mettananda

    Citation: BMC Pediatrics 2021 21:41

    Content type: Case report

    Published on:

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